Like other odontogenic neoplasms, it is thought to arise. Calcifying cystic odontogenic tumor a case report and. Immunohistochemical assessment of odontogenic tumors using smooth muscle actina short study. Even the cystic lesion has apparent neoplastic potential but most. On radiographs, the calcifying odontogenic cyst appears as a unilocular radiolucency dark area. Observation an asymptomatic welllimited radioluscent mandibular lesion was fortuitously discovered on the panoramic xray in the periapical region of teeth no. The origin of this tumor is controversial, and it is believed that it can be derived from oral epithelium, reduced enamel epithelium, intermediate stratum or even dental lamina remnants 1, 2. Calcifying odontogenic cyst article about calcifying. Adenomatoid odontogenic tumor with features of calcifying epithelial odontogenic tumor. Philipsen hp, reichart pa, zhang kh, nikai h, yu qx. The calcifying odontogenic cyst is an uncommon benign cyst of odontogenic origin, characterized by an ameloblastomalike epithelium with ghost cells that may. Mar 10, 2015 it is a developmental odontogenic cyst, and its occurrence constitutes about 0.
Surgical management of a large calcifying epithelial. Calcifying odontogenic cyst of anterior maxilla with. Clearcell variant of calcifying epithelial odontogenic tumor pindborg tumor in the mandible chingyi chen1, chungwei wu2, wenchen wang1,3, limin lin1,3 and yukkwan chen1,3 we present an uncommon case female patient aged 59 years of the clearcell variant of calcifying epithelial odontogenic tumor. Calcifying epithelial odontogenic tumor radiology reference. Ameloblastoma, calcifying epithelial odontogenic tumor, and glandular odontogenic cyst show a distinctive immunophenotype with some myoepithelial antigen expression. Pdf calcifying epithelial odontogenic cyst of the mandible.
Calcifying definition of calcifying by the free dictionary. The calcifying odontogenic cyst coc is a simple cyst lined by ameloblastomalike epithelium with ghost cells. It is most common in people in their second to third decades but can be seen at almost any age. Odontogenic fibroma, adenomatoid odontogenic tumor, calcifying epithelial odontogenic tumor, ameloblastic fibroodontoma, and calcifying odontogenic cyst. The calcifying epithelial odontogenic tumor ceot is a rare benign tumor of the jaws. Calcifying odontogenic cyst is a rare lesion of the jaws first described as a distinct entity by gorlin et al. Calcifying epithelial odontogenic tumor article about. It was first described by pindborg in 1955 who reported three benign odontogenic tumor arising from the mandible. This article is from korean journal of pathology, volume 48. It is seen more frequently in female than in male patients. Calcifying epithelial odontogenic tumor pindborgs tumor. Like other odontogenic neoplasms, it is thought to arise from the epithelial element.
Calcifying epithelial odontogenic cyst of the mandible figueiredo. Calcifying epithelial odontogenic cyst of the mandible. Calcifying epithelial odontogenic tumor ceot, also known as a pindborg tumor, previously has been called adenoid adamintoblastoma, unusual ameloblastoma and cystic odontoma is typically located in the premolar and molar region of the mandible, although up to a third are found in the maxilla. Pdf ameloblastoma, calcifying epithelial odontogenic. Calcifying epithelial odontogenic tumor definition of. Mar 21, 2017 radiograph of a calcifying odontogenic cyst of the maxilla. Calcifying odontogenic cyst is a wellcircumscribed, solid, or cystic lesion derived from odontogenic epithelium which develops from reduced enamel epithelium. Clinical appearance of the calcifying odontogenic cyst in the region of the upper canine. The calcifying odontogenic cyst coc was first delineated in 1962. Extension of calcifying epithelial odontogenic tumor to.
Calcifying odontogenic cyst was first described by gorlin et al. It strikes distinct age groups, with an average patient age being 50 years. Immunohistochemical demonstration of an enamel sheath protein, sheatlin, in odontogenic tumors. A cyst is defined as an epitheliumlined pathologic cavity. The epithelial lining was 34 cells thickness exhibiting globules of eosinophilic structure suggestive of ghost cells figures figures3 3 and and4. In calcifying epithelial odontogenic tumor cases, positivity to alphasma marker was evident in about 42% of the cells per high power field. Calcifying epithelial odontogenic tumour associated with. Introduction calcifying odontogenic cysts coc represent 0. The calcifying epithelial odontogenic tumor ceot is a rare benign epithelial odontogenic neoplasm of slow growth that is locally aggressive and tends to invade bone and adjacent soft tissue.
Calcifying odontogenic cyst with atypical features balaji. A majority of them are remnants of odontogenic apparatus. Calcifying epithelial odontogenic tumor of the posterior. Calcifying odontogenic cyst is a rare and specific lesion with properties of a tumor that can appear anywhere on the body and have properties of a cyst. Odontogenic cyst are a group of jaw cysts that are formed from tissues involved in odontogenesis tooth development. Calcifying epithelial odontogenic cyst associated with complex.
The calcifying ghost cell odontogenic tumor or the calcifying odontogenic cyst the calcifying ghost cell odontogenic tumor or the calcifying odontogenic cyst fejerskov, o krogh, j. Coc was established and the patient has been disease free for 5 years. Clearcell variant of calcifying epithelial odontogenic. The calcifying odontogenic cyst coc is a developmental odontogenic cyst and its occurrence constitutes about 0. The patient was sent for surgical exploration under local anesthesia and the lesion was enucleated using caldwellluc approach and the entire lesion was excised along with the impacted third. Calcifying epithelial odontogenic tumor, also known as pindborg tumor, is a rare, benign, locally aggressive tumor that occurs in the same age range and in the same jaw sites as ameloblastoma. Study on the origin and nature of the adenomatoid odontogenic tumor by immunohistochemistry. The center of the ball of cells then has a higher protein. Lateral periodontal cyst calcifying odontogenic gorlin cyst. Microscopical examination revealed features similar to that of ceot in addition to the epithelial cyst lining.
Pdf calcifying odontogenic cyst or gorlin cyst, was first described by gorlin. Calcifying odontogenic cyst gorlin cyst ddmfr oral. Case report clearcell variant of calcifying epithelial odontogenic tumor pindborg tumor in the mandible chingyi chen1, chungwei wu2, wenchen wang1,3, limin lin1,3 and yukkwan chen1,3 we present an uncommon case female patient aged 59 years of the clearcell variant of calcifying epithelial odontogenic tumor. Calcifying epithelial odontogenic tumor ceot was first described by the dutch pathologist jens jorgen pindborg in 1955. Soft tissue pathological changes are hyperplasias,inflammation and calcification are the common. Some of the ghost cells appear to undergo dystrophic calcification figure 5. Calcifying odontogenic cyst synonyms, calcifying odontogenic cyst pronunciation, calcifying odontogenic cyst translation, english dictionary definition of calcifying odontogenic cyst. Calcifying epithelial odontogenic pindborg tumor in a. Calcifying epithelial odontogenic tumor an overview.
Intrabony cysts are most common in the jaws, because the mandible and maxilla are the only bones with. Radiograph of a calcifying odontogenic cyst with well demarcated margins extending from the right to the left premolar regions of the mandible. It is a rare developmental odontogenic cyst with notable presence of histopathological features which include a cystic lining demonstrating characteristic ghost epithelial cells with a propensity to calcify. Calcifying epithelial odontogenic tumor, calcifying epithelial odontogenic cyst, ghost cells, gorlin cyst. The calcifying odontogenic cyst gorlin cyst pure facts. It is considered a rare and benign odontogenic neoplasm, and its origin is exclusively epithelial 2. Provisional diagnosis of calcifying epithelial odontogenic cyst, odontogenic keratocyst, adenomatoid odontogenic tumor, and dentigerous cyst was made. Calcifying odontogenic cyst coc, first described as a separate entity by gorlin et al. The calcifying ghost cell odontogenic tumor deepdyve.
There is a welldemarcated margin and calcifications suggestive of tooth material. Pindborg tumor, calcifying epithelial odontogenic tumor, maxillary sinus 1. Apr 22, 20 the calcifying odontogenic cyst gorlin cyst. The pathological changes associated with the impacted 3rd molar are cystic changes which include dentigerous cysts, odontogenic keratocyst and calcifying odontogenic cyst. Calcifying odontogenic cyst how is calcifying odontogenic. Synonyms for calcifying odontogenic cyst in free thesaurus. These findings are not specific and simulate an ameloblastoma, dentigerous cyst, or other odontogenic tumors. Calcifying odontogenic cyst how is calcifying odontogenic cyst abbreviated. Introduction the calcifying epithelial odontogenic tumor ceot was first described by the danish pathologist jens jorgen pindborg in 19551. Although the condition is often described as being cystic 85% of the cases, a significant percentage of calcifying odontogenic cysts grow as more solid, seemingly neoplastic proliferations, and the term dentinogenic ghost cell tumor has been used to describe these lesions. Myxoma, and odontogenic fibroma are the commonest neoplasms.
Calcifying odontogenic cyst associated with ameloblastoma and adenomatoid odontogenic tumor old male patient with a large coc associated with an impacted 38 and involving the left body and angle of mandible. It was previously described as an adenoid adamantoblastoma, unusual ameloblastoma and a cystic odontoma. Adenomatoid odontogenic tumor aot mixed calcifying epithelial odontogenic tumor ceot calcifying odontogenic cyst gorlin cyst odontoma mixed lesion cementoblastoma. Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic. Calcifying odontogenic cyst synonyms, calcifying odontogenic. This entity constituted an epitheliumlined sac filled with fluid or semi fluid material. Odontogenic cysts are closed sacs, and have a distinct membrane derived from rests of odontogenic epithelium.
Introduction a cyst is an epithelium lined sac containing fluid or semifluid material the epithelial cells first proliferate and later undergo degeneration and liquefaction grow by expansion, causing displacement of adjacent teeth 3. A propensity for the mandibular molar region versus the premolar maxilla has been reported. Radiograph of a calcifying odontogenic cyst of the maxilla. Extension of calcifying epithelial odontogenic tumor to the. Clearcell variant of calcifying epithelial odontogenic tumor. The epithelial cells may form rosettelike structures around a central space, which may be empty or contain a small amount of eosinophilic material figure 5. We describe the finding and the treatment of a coc in a 67yearold female. Dec 06, 2017 the calcifying epithelial odontogenic tumor ceot is a rare benign tumor of the jaws. Calcifying epithelial odontogenic cyst s are thought to be a unicystic process, which develop from the reduced enamel epithelium or remnants of odontogenic epithelium in the follicle, gingival tissue or bone. Glandular odontogenic cyst goc is a rare developmental lesion that is considered a distinct entity because of its uncommon histopathological characteristics. Chronic osteomyelitis mixed florid cementoosseous dysplasia mixed fibrous dysplasia mixed cementoossifying fibroma 2nd stage paget disease. With this we made a final diagnosis of calcifying ghost cell odontogenic cyst. Find out information about calcifying odontogenic cyst.
The calcifying epithelial odontogenic tumor ceot, also known as a pindborg tumor, is an odontogenic tumor first recognized by the danish pathologist jens jorgen pindborg in 1955. Introduction the calcifying epithelial odontogenic tumor ceot, is a benign neoplasm o f odontogenic origin. The calcifying epithelial odontogenic cyst ceoc is a developmental odontogenic cyst, which was first categorized as a distinct entity by gorlin. The computerized tomography in coronal plane revealed a hypodense lesion in the posterior.
The lesion is unusual in that it has some features of a cyst but. The calcifying odontogenic cyst or gorlin cyst was originally identified as an independent condition by gorlin in 1962 year. Odontogenic cysts and tumors ppt linkedin slideshare. Pdf calcifying epithelial odontogenic cyst a case report. Who defined it as a cystic lesion in which the epithelial lining shows a welldefined basal layer of columnar cells, an overlying layer that is often many cells thick and that may resemble stellate reticulum, and masses of ghost epithelial cells that may be in the epithelial cyst lining or in the. In 1963, shafer and colleagues coined the term pindborgs tumor. Since experience with the calcifying odontogenic cysts is still limited, it may be worth while to report a case of this type. Enlarged epithelial cells with eosinophilic cytoplasm and no nucleus ghost cells were. Calcifying epithelial odontogenic tumor ceot is a rare neoplasm, which accounts for odontogenic tumor ceot is a rare benign neoplasm. Developmental inflammatory odontogenic keratocyst radicular dentigerous cyst residual eruption cyst paradental gingival cyst of infants gingival cyst of adults lateral periodontal cyst calcifying odontogenic cyst glandular odontogenic cyst prepared by dr sundeep s bhagwath.
The peripheral coc is a rare lesion and few reports have been published considering its clinical and histopatholo. A rare case report lianacristinamelocarneiro costa 1. Females are more commonly affected than males with a ratio of 2. Abstract calcifying epithelial odontogenic tumors ceots and ghost cell odontogenic tumors gcots are characteristic odontogenic origin epithelial tumors which produce calcifying materials from transformed epithelial tumor cells. Provisional diagnosis based on the radiographical and clinical observations was that of a dentigerous cyst. An abnormal membranous sac in the body containing a gaseous, liquid, or semisolid substance. Calcifying ghost cell odontogenic cyst cgcoc is a relatively uncommon odontogenic lesion characterized by varied clinical, radiographical features and biological behavior. It has morphological similarities to other lesions, which makes its diagnosis challenging for pathologists. According to the current 2005 classification of the world health organization, both parakeratizied odontogenic keratocyst and calcifying odotogenic cyst have neoplastic characteristics, thus renamed as keratocystic odontogenic tumor and calcifying odotogenic tumor, respectively. Adenomatoid odontogenic tumor mimicking a periapical radicular cyst.
Calcifying epithelial odontogenic tumor of the maxilla. Calcifying odontogenic cyst gorlin cyst ddmfr oral and. Calcifying epithelial odontogenic cyst associated with. A case of calcifying epithelial odontogenic tumour is described. Calcifying epithelial odontogenic pindborg tumor in a child. Who defined it as a cystic lesion in which the epithelial lining shows a welldefined basal layer of columnar cells, an overlying layer that is often many cells thick and that may resemble stellate reticulum, and masses of ghost epithelial cells that may be in the epithelial cyst lining or in the fibrous. Here is reported the case of a 21yearold female patient with a ceot in the left mandibular posterior region. In addition, the calcifying odontogenic cyst may be associated with other odontogenic tumors, most commonly odontoma.
The lesion is unusual in that it has some features of a cyst but also has many characteristics of a solid neoplasm cysts and tumors of odontogenic origin. Glandular odontogenic cyst the glandular odontogenic cyst goc is a rare lesion, accounting for just 0. Cysts of the maxilla, mandible, and perioral regions vary markedly in histogenesis, incidence, behavior, and treatment. The paper reports on two new cases of calcifying odontogenic cysts, and gives a survey of 50 cases reported in the literature. Current concepts and occurrence of epithelial odontogenic. The calcifying epithelial odontogenic tumor ceot was described in 1955 by jens jorgen pindborg, a dutch pathologist 1, 2. Pdf the calcifying epithelial odontogenic cyst ceoc is a developmental.
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